3D Bioprinting

3D Printing is no longer news although I suspect most people haven’t heard of it yet. In fact there is a company within a couple of km of my office in Albany already successfully offering a variety of 3D printing services, incidentally called 3D Print. Another Aucklander, well known internationally in the  3D printing with RepRap is Vik Oliver, seen here with one of his machines.

When I heard that Richie McCaw was injured and after surgery was going to miss around 6 matches after having a titanium screw in his foot, my first reaction was, as most Kiwis, just what we need in Rugby World Cup year as he is such an amazing skipper and we want him there leading the All Blacks. Then I thought about so many other sports people who suffer injuries all the time given that they are putting their bodies on the line professionally.

Imagine a technology that rebuilds or repairs body tissue, bones, ligaments, even organs in vivo, using micro surgery techniques that mean people recover far more quickly, naturally and potentially therefore stronger than before.

Using the same types of technologies as conventional 3D printing, it will soon be possible to pattern and assemble, layer by layer, functioning living tissue, as well as non living substitutes such as ceramic and titanium according to Vladimir Mironov, an associate professor and director of the Advanced Tissue Biofabrication Center at the Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina. He is also currently making waves about growing in vitro meat, something I have previously blogged about.

So this is a relatively new technology and I don’t know that it has been tested on humans yet, but the technology is already commercially available from companies such as envisionTEC.

Imagine the good this technology could do for people with problems from injuries, burns, through to the huge numbers of people who die for lack of organs for transplant.

The following video shows how bioprinters will be used in the long term. The technology will also be used to create human tissues which can be used for drug testing instead of using animals.

Of course if tissues and organs are made using material from the host, we can eliminate problems such as donor organ rejection.

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More on In Vitro Meat

A couple of years ago I wrote about the potential to grow your own food including  in vitro meat. The first experiments produced something rubbery and inedible, but things have moved on since then.

For a country like New Zealand the idea of creating artificial meat is anathema. We made history in 1882 when the SS Dunedin successfully arrived in London carrying 4931 refrigerated carcasses  of  mutton, lamb and pork.

Whilst in the past meat represented better than 50% of NZ’s export revenue, in 2009 it was a modest 13.2%. On the other hand biotech is becoming so important in New Zealand that it has even made the Secondary School curriculum. Significant consideration is being given to Animal Biofarming in NZ as evidenced by this comprehensive document from the NZ Foundation for Research Science and Technology FRST.

Why would you consider doing something like this. Simple really. A large chunk of the population of the world is hungry and unable to feed itself. Over 1 Billion people fit the definition of living in hunger. That’s more than 3 times the population of the USA! Then there’s water. There is debate in some places that there is no water crisis, but fresh water represents only 3% of the total water on the planet. I won’t go into the countries where drinking water is an issue, its common knowledge and drought as a news search on Google draw almost 13,000 results.

According to Fred Pearce who wrote the book When the Rivers Run Dry, it requires around 24,000 liters of water to grow the feed to make a kilo of beef, or 2,400 liters for a Quarter Pounder.

Now while a cow also produces leather and pet food, and other product a massive amount of each beast is expensive waste product, even if some of it goes back in the ground as fertilizer. Wouldn’t it make sense to be able to just make the meat if you could?

I’ve focused on some of the why’s. I haven’t even touched on the widely held ethical views on growing animals purely so we can eat them. I definitely like my meat, don’t get me wrong. Anyway I will leave with a link to the In Vitro Meat Foundation and a quote from Winstone Churchill in 1932:

“Fifty years hence (…) we shall escape the absurdity of growing a whole chicken in order to eat the breast or wing, by growing these parts separately under a suitable medium”

The last word goes to Jason Metheny of New Harvest

In Vitro Grown Meat – Feeding the Future

The other day I was thinking about the proposed manned Mars trip and trying to get my head around how to feed a number of astronauts for a 1,000 day trip in a small space craft. The thought was started while reading an article about Cosmic Rays, which are a potential threat to astronauts, but that is entirely another discussion.

Our planet today has a number of problems in being able to feed a growing population, which combined with major droughts in some parts of the world and heavy rains in others, exacerbated or caused by global warming, we are already in a situation of food crisis. If you are reading this blog, you probably don’t personally have a problem, but the problem is nevertheless there.

The first problem, which is the most difficult, is poverty. According to the World Hunger Education Service, almost 1 billion people have incomes of no more than US$1 per day. That doesn’t buy a whole lot of food.

Given the climate conditions, growth of population, finding the ground to plant sufficient crops that are not labour and water intensive is difficult and another issue is lack of certain key needs such as proteins.

One option for this going forward could be to grow food in vats. All kinds of food could be grown in vats and they have been doing this in Science Fiction books for close to 100 years. Now vegetable matter, fungus and yeast are relatvely easy, meat is a different story.

As I continued on my thread, I was thinking about chicken being one of the most popular if not the most popular meat being eaten today. The way they bread chickens in poultry farms for meat or eggs is commonly regarded as cruelty although the farmers will argue that they have little choice.

Tissue engineering is a science that has been around for quite a while. In fact if you have a child today, you already have the option of harvesting the stem cells from your baby’s umbilical cord. Cordbank in New Zealand offers cryogenic storage of your baby’s umbilicus, so that if your child ever got cancer and needed fresh stem cells, they are there and ready. The Stem Cells have your child’s exact DNA, so there are no risks of rejection if they are needed and at this stage they have no age damage. Stem cells have the inherent ability to become pretty much any human organ.

Tissue engineering has the potential to not only save lives, but also to prolong it. In future it could be used to help people recover from brain injuries and perhaps condiions such as Parkinsons Disease. It can help with regenerating heart tissue and much much more.

It can also be used to generate food. Distasteful as it may sound, I’m sure in the future if you were offered fish chunks that were made in a lab in a double blind test with real fish of the same sort, you would struggle to tell whch one was real. This isn’t Sci-Fi, it has already been achieved. One of the motives for this research was the type of space travel I mentioned at the beginning of this blog.

If you could eat nice white chicken meat that was tender and had the same texture you expected, but no chickens were mistreated or battery grown in cramped conditions, i.e. no sentience and no pain. Why wouldn’t you? If you could provide healthy food to millions of people in environments where they otherwise couldn’t get it and would suffer from malnutrition and eventually die a horrible death, why not?

I’m not sure what, if any research in tissue engineering is happening in NZ, but we have the credentials to do it and government support for biotechnology. In the medical world there is plenty happening such as the orthopaedic research at Otago University. If I’m lucky, I could live longer because of this research. I would love to see 120 or 130 years on this planet, and not vegetating in a rest home, wouldn’t you?